Description

20-(Hydroxymethyl)-4-Methyl-4-Aza-2-Oxapregnan-3-One is a high-purity synthetic steroid derivative, specifically a modified pregnane structure, which serves as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of novel therapeutic agents, particularly in the development of neuroactive steroids and hormone modulators. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of next-generation central nervous system (CNS) and endocrine-targeting drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent neurosteroids and other bioactive steroid-based molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new therapeutic candidates targeting GABA-A receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) within regulated GMP environments.

Basic Information

Product Name	20-(Hydroxymethyl)-4-Methyl-4-Aza-2-Oxapregnan-3-One
CAS No.	96000-11-2
Molecular Formula	C₂₂H₃₅NO₃
Molecular Weight	361.52 g/mol
Synonyms	4-Methyl-4-aza-2-oxapregnan-3-one, 20-(hydroxymethyl)-; 20-Hydroxymethyl-4-methyl-4-aza-2-oxapregnan-3-one; Ganaxolone Intermediate; CCD-1042; (3α,5β)-20-(Hydroxymethyl)-3-hydroxy-4-methyl-4-aza-21-norcholan-2-one
EINECS	Contact for details

Quality Control

Our 20-(Hydroxymethyl)-4-Methyl-4-Aza-2-Oxapregnan-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets exacting standards for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.