Description

4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 3-(Chloromethyl)-3-Methyl-7-Oxo-, [2S-(2α,3β,5α)]- (9Ci) is a high-purity, advanced pharmaceutical intermediate with the CAS number 95835-17-9. This compound is a key synthon in the synthesis of modern β-lactam antibiotics, offering a critical chiral scaffold for constructing molecules with targeted biological activity. It is essential for research and development laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the production of novel antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of next-generation β-lactam antibiotics, including certain penems and carbapenems.
• Antibacterial Drug Research: Used in medicinal chemistry for the research and development of new antibacterial compounds targeting resistant bacterial strains.
• Fine Chemical Synthesis: Serves as a specialized chiral intermediate in multi-step organic syntheses requiring a complex, functionalized bicyclic structure.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in pilot plants and commercial manufacturing.
• Biochemical Research: Utilized in studies investigating the mechanism of action and structure-activity relationships (SAR) of β-lactam-based inhibitors.

Basic Information

Product Name	4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 3-(Chloromethyl)-3-Methyl-7-Oxo-, [2S-(2α,3β,5α)]- (9Ci)
CAS No.	95835-17-9
Molecular Formula	C9H12ClNO3S
Molecular Weight	249.71 g/mol
Synonyms	(2S,3R,5R)-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, (2S,3R,5R)-; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(chloromethyl)-3-methyl-7-oxo-, (2S,3R,5R)-; A key penem intermediate; Chloromethyl penem acid
EINECS	Contact for details

Quality Control

Our 4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.