Description

n-(4-Azido-3-Iodophenethyl)Spiperone is a specialized, high-purity chemical building block designed for advanced research and development. This compound is critical for applications requiring precise molecular tagging and receptor binding studies due to its unique azido and iodo functional groups. It is primarily utilized by pharmaceutical researchers, radiochemists, and academic institutions engaged in the development of novel diagnostic agents and targeted therapies.

Application

• Radiopharmaceutical Precursor: Acts as a key intermediate in the synthesis of iodine-123 or iodine-131 labeled compounds for Single Photon Emission Computed Tomography (SPECT) imaging.
• Photoaffinity Labeling: The azido group enables covalent cross-linking to biological targets upon UV irradiation, essential for studying protein-ligand interactions and receptor mapping.
• Dopamine Receptor Research: Used as a derivatized analog of spiperone for investigating dopamine D2 receptor binding sites and kinetics.
• Bioconjugation Chemistry: Serves as a heterobifunctional linker for attaching various probes, drugs, or markers to biomolecules via click chemistry or nucleophilic substitution.
• Chemical Biology Tool: Employed in the development of activity-based probes to visualize and understand complex biological processes in real-time.
• Process Development: Used in scaling up the synthesis of novel therapeutic candidates for preclinical and clinical evaluation.

Basic Information

Product Name	n-(4-Azido-3-Iodophenethyl)Spiperone
CAS No.	95754-28-2
Molecular Formula	C23H25IN4O2
Molecular Weight	540.38 g/mol
Synonyms	4-Azido-3-iodo-N-(8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)benzeneethanamine; N-(2-(4-Azido-3-iodophenyl)ethyl)spiperone; Azidoiodophenethylspiperone; Iodoazidophenethylspiperone; 95754-28-2; Spiperone azido iodo derivative; Photoaffinity label for D2 receptors
EINECS	Contact for details

Quality Control

Every batch of n-(4-Azido-3-Iodophenethyl)Spiperone is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.