Description

Fmoc-4-Nitro-L-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the 4-nitrophenylalanine moiety into peptide sequences, enabling the study of protein structure, function, and interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies developing novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide chains.
• Pharmaceutical Research: Used in the development and production of peptide drugs, vaccines, and targeted therapeutic agents that incorporate nitroaromatic functionalities.
• Chemical Biology & Proteomics: Employed to create peptide substrates, inhibitors, or activity-based probes for studying enzyme mechanisms and protein-protein interactions.
• Material Science: Incorporation into peptidomimetics and functionalized polymers to create novel biomaterials with specific electronic or optical properties derived from the nitro group.
• Agrochemical Research: Potential use in the synthesis of bioactive peptide analogs for crop protection and development.

Basic Information

Product Name	Fmoc-4-Nitro-L-Phenylalanine
CAS No.	95753-55-2
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine; Fmoc-Phe(4-NO2)-OH; Fmoc-4-Nitro-L-Phe-OH; N-α-Fmoc-4-nitro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-nitrophenyl)propanoic acid; Fmoc-L-4-nitrophenylalanine; N-Fmoc-4-nitro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-4-Nitro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.