Description

3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-5-Ethyl-Arabinouridine is a key fluorinated nucleoside derivative, specifically engineered as a sophisticated building block in advanced pharmaceutical synthesis. This compound is valued for its role in the development of novel antiviral and anticancer therapeutics, where its modified sugar moiety is critical for enhancing metabolic stability and target binding affinity. It is an essential intermediate for research institutions and pharmaceutical companies engaged in the synthesis of next-generation nucleoside analogs and prodrugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting viral polymerases, particularly for hepatitis and herpesvirus families.
• Oncology Research: Serves as a building block for creating chemotherapeutic agents that inhibit cancer cell proliferation.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleoside-based drugs.
• Biochemical Probe Development: Utilized in creating labeled compounds for studying enzyme mechanisms and metabolic pathways.
• Process Chemistry & Scale-up: A key material for process development and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-5-Ethyl-Arabinouridine
CAS No.	95740-18-4
Molecular Formula	C25H23FN2O7
Molecular Weight	482.46 g/mol
Synonyms	2'-Deoxy-2'-fluoro-5-ethylarabinouridine 3',5'-dibenzoate; 5-Ethyl-2'-deoxy-2'-fluorouridine 3',5'-dibenzoate; 2'-Fluoro-5-ethyl-2'-deoxyarabinouridine 3',5'-dibenzoate; 5-Ethyl-1-[(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; NSC 678694; Fluorinated Arabinouridine Derivative; 2'-F-5-Et-AraU 3',5'-diBz
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-5-Ethyl-Arabinouridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications is available with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.