Description

5,10-Dideazatetetrahydrofolic acid is a synthetic folate analog and a key intermediate in the development of novel chemotherapeutic agents. This compound is of significant interest in pharmaceutical research due to its role as a potent inhibitor of enzymes in the folate metabolic pathway, such as glycinamide ribonucleotide formyltransferase (GARFTase). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of targeted anti-cancer drugs, particularly antifolates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antifolate chemotherapeutic agents.
• Biochemical Research: Used as a reference standard and tool compound in studies of folate metabolism and enzyme inhibition kinetics.
• Oncology Drug Discovery: Serves as a core scaffold for developing inhibitors targeting purine biosynthesis in cancer cells.
• Enzyme Inhibition Studies: Employed to investigate the mechanism and potency of GARFTase and other folate-dependent enzyme inhibitors.
• Academic Research: Utilized in universities and research labs for fundamental studies in medicinal chemistry and biochemistry.

Basic Information

Product Name	5,10-Dideazatetrahydrofolic acid
CAS No.	95693-76-8
Molecular Formula	C19H23N7O5
Molecular Weight	429.43 g/mol
Synonyms	5,10-Dideazatetrahydrofolate; 5,10-DDATHF; Lometrexol intermediate; 5,10-Dideaza-5,6,7,8-tetrahydrofolic acid; NSC 127755; (6R)-5,10-Dideazatetrahydrofolic acid; 5,10-Dideaza-THF; Antifolate intermediate
EINECS	Contact for details

Quality Control

Our 5,10-Dideazatetrahydrofolic acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, storage at -20°C under inert atmosphere is recommended. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.