Description

3-Acetoxymethyl-7-Chloro-3-Cephem-4-Carboxylate-1,1-Dioxide tert-Butylester is a high-purity, advanced pharmaceutical intermediate belonging to the cephalosporin class of β-lactam antibiotics. This compound is critical for the synthesis of next-generation antibiotic APIs, offering a key building block for developing potent, broad-spectrum antibacterial agents. It is primarily required by pharmaceutical manufacturers and R&D facilities engaged in the production and development of advanced cephalosporin drugs.

Application

• Key Intermediate in Cephalosporin Synthesis: Serves as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for 7-chloro cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, development, and optimization of new β-lactam antibiotic candidates with improved efficacy.
• Process Chemistry & Scale-Up: Employed in pilot plants and commercial manufacturing processes to produce bulk antibiotic drugs under controlled GMP environments.
• Antibacterial Agent Development: Integral for creating compounds targeted against resistant bacterial strains, contributing to the fight against antimicrobial resistance (AMR).

Basic Information

Product Name	3-Acetoxymethyl-7-Chloro-3-Cephem-4-Carboxylate-1,1-Dioxide tert-Butylester
CAS No.	95672-01-8
Molecular Formula	C15H19ClN2O7S
Molecular Weight	406.84 g/mol
Synonyms	7-Chloro-3-(acetoxymethyl)-3-cephem-4-carboxylic acid 1,1-dioxide tert-butyl ester; tert-Butyl 7-chloro-3-(acetoxymethyl)-4-oxo-2-thia-1-azabicyclo[4.2.0]oct-5-ene-5-carboxylate 1,1-dioxide; 3-(Acetoxymethyl)-7-chloro-3-cephem-4-carboxylic acid tert-butyl ester 1,1-dioxide; 7-Chloro cephalosporin tert-butyl ester intermediate; 95672-01-8
EINECS	Contact for details

Quality Control

Our 3-Acetoxymethyl-7-Chloro-3-Cephem-4-Carboxylate-1,1-Dioxide tert-Butylester is manufactured under strict quality management systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.