Description

7,10-Bis-o-(2,2,2-Trichloroethoxycarbonyl)-10-Deacetylbaccatin Iii is a key synthetic intermediate derived from the taxane diterpenoid skeleton, specifically designed for advanced pharmaceutical research and synthesis. This compound is of significant value for its role in the semi-synthetic production of potent anticancer agents, where precise chemical modification is critical. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing novel taxane-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step semi-synthesis of paclitaxel (Taxol®) and docetaxel, which are cornerstone chemotherapeutic agents.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies to develop new taxane derivatives with improved efficacy or reduced side effects.
• Process Chemistry Development: Serves as a benchmark compound for optimizing and scaling up synthetic routes for complex natural product derivatives.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC or LC-MS method development and validation.
• Bioconjugation Studies: The reactive trichloroethoxycarbonyl (Troc) protecting groups make it a candidate for exploring targeted drug delivery systems.

Basic Information

Product Name	7,10-Bis-o-(2,2,2-Trichloroethoxycarbonyl)-10-Deacetylbaccatin Iii
CAS No.	95603-44-4
Molecular Formula	C33H39Cl6O13
Molecular Weight	832.45 g/mol
Synonyms	10-Deacetylbaccatin III 7,10-bis(2,2,2-trichloroethoxycarbonyl) ether; 7,10-Bis-Troc-10-DAB III; 10-DAB III 7,10-bis-Troc; Baccatin III, 10-deacetyl-, 7,10-bis(2,2,2-trichloroethyl carbonate); (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-4,6,9,11,12a-pentahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-2,4,10-triyl tris(2,2,2-trichloroethyl) dicarbonate acetate
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Quality Control

Our 7,10-Bis-o-(2,2,2-Trichloroethoxycarbonyl)-10-Deacetylbaccatin Iii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.