Description

2-Bromo-2-Deoxy-5-Methyluridine-3,5-Diacetate is a key halogenated nucleoside derivative, serving as a critical synthetic intermediate in the development of novel antiviral and anticancer agents. Its modified structure allows for targeted incorporation into nucleic acid chains, making it invaluable for probing biochemical pathways and developing therapeutic compounds. This high-purity building block is essential for pharmaceutical R&D laboratories and fine chemical manufacturers focused on nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potent antiviral and antineoplastic nucleoside analogs.
• Biochemical Research: Used as a modified substrate to study enzyme mechanisms, DNA/RNA synthesis, and cellular metabolism.
• Antiviral Drug Development: Serves as a building block for creating novel compounds targeting viral polymerases and replication.
• Oncology Research: Employed in the design and synthesis of chemotherapeutic agents that interfere with cancer cell proliferation.
• Labeled Compound Synthesis: A starting material for preparing isotopically labeled (e.g., C-13, N-15) nucleosides for metabolic tracing studies.
• Pro-drug Development: The acetyl-protected groups make it a useful intermediate for creating bio-reversible, membrane-permeable pro-drug forms of active nucleosides.

Basic Information

Product Name	2-Bromo-2-Deoxy-5-Methyluridine-3,5-Diacetate
CAS No.	95585-76-5
Molecular Formula	C₁₄H₁₇BrN₂O₈
Molecular Weight	421.20 g/mol
Synonyms	5'-O-Acetyl-2-bromo-2'-deoxy-5-methyluridine 3'-acetate; 2-Bromo-2'-deoxy-5-methyluridine 3',5'-diacetate; 1-[(2R,4S,5R)-4-Acetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl]-5-methyl-2-bromopyrimidine-2,4(1H,3H)-dione; 2-Bromo-5-methyl-2'-deoxyuridine 3',5'-di-O-acetate; BrdUrd-3',5'-diacetate (derivative); 2-Bromo-5-methyluridine-3',5'-diacetate
EINECS	Contact for details

Quality Control

Our 2-Bromo-2-Deoxy-5-Methyluridine-3,5-Diacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.