Description

γ-tert-Butyl Aminopterin is a chemically modified derivative of the classic antifolate compound, aminopterin. This structural modification enhances its stability and can alter its biological activity profile, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutic agents. The compound is supplied with a focus on high purity and batch-to-batch consistency to support critical R&D workflows.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antifolate drugs and targeted cancer therapies.
• Biochemical Research: Used as a reference standard or active compound in studies investigating folate metabolism, enzyme inhibition (e.g., dihydrofolate reductase), and cellular proliferation pathways.
• Anticancer Agent Development: Investigated for its potential efficacy and modified pharmacokinetic properties compared to parent compounds in oncology research.
• Chemical Biology Probes: Employed in the design and development of molecular probes to study specific biological targets and mechanisms of action.
• Process Chemistry: Used in scale-up and optimization studies for the production of more complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	γ-tert-Butyl Aminopterin
CAS No.	95484-98-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-[(2,4-Diamino-6-pteridinyl)methylamino]benzoic Acid; N-(tert-Butyl)-4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoic Acid; γ-tert-Butylaminopterin; tert-Butyl Aminopterin; Aminopterin tert-butyl derivative
EINECS	Contact for details

Quality Control

Our γ-tert-Butyl Aminopterin is manufactured under controlled conditions to ensure high purity and reliability for research applications. Each batch undergoes rigorous analytical testing, including identity confirmation and purity assessment via advanced chromatographic methods. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.