Description

3β-Hydroxy-20-Oxopregn-5-Ene-16β-Carbonitrile is a high-purity steroidal intermediate of significant importance in pharmaceutical research and development. This compound serves as a critical building block for the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the fields of endocrinology and metabolic disorders. The consistent quality and reliable supply of this intermediate are paramount for ensuring the integrity of downstream synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of advanced steroid hormones and related bioactive molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates targeting steroid receptors.
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in scaling up synthetic routes for pilot plant and commercial manufacturing of steroid APIs.
• Biochemical Research: Utilized in studies investigating steroid biosynthesis pathways and enzyme inhibition.

Basic Information

Product Name	3β-Hydroxy-20-Oxopregn-5-Ene-16β-Carbonitrile
CAS No.	95341-23-4
Molecular Formula	C22H31NO2
Molecular Weight	341.49 g/mol
Synonyms	16β-Cyano-3β-hydroxy-5-pregnen-20-one; Pregna-5-ene-16β-carbonitrile, 3β-hydroxy-20-oxo-; 3β-Hydroxypregn-5-en-20-one-16β-carbonitrile; (3β,16β)-3-Hydroxy-16-cyanopregn-5-en-20-one; 16β-Cyanopregnenolone; 3β-Hydroxy-16β-cyanopregn-5-en-20-one
EINECS	Contact for details

Quality Control

Our 3β-Hydroxy-20-Oxopregn-5-Ene-16β-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.