Description

(S)-3-Hydroxyglutarate Ethyl is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its defined stereochemistry makes it a critical precursor for the development of pharmaceutical actives, fine chemicals, and complex natural products. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of statin analogs, enzyme inhibitors, and other bioactive molecules.
• Asymmetric Synthesis: Serves as a versatile building block in stereoselective reactions to construct complex molecular architectures.
• Biochemical Research: Used in metabolic pathway studies and as a substrate or inhibitor for enzymes like hydroxyglutarate dehydrogenase.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Agrochemical Development: Potential precursor for chiral active ingredients in crop protection agents.
• Academic & R&D: Valuable reagent for methodological development in organic chemistry and catalysis research.

Basic Information

Product Name	(S)-3-Hydroxyglutarate Ethyl
CAS No.	95310-87-5
Molecular Formula	C7H12O5
Molecular Weight	176.17 g/mol
Synonyms	Ethyl (S)-3-Hydroxyglutarate; (S)-Ethyl 3-Hydroxyglutarate; (3S)-3-Hydroxypentanedioic Acid Diethyl Ester; (S)-3-Hydroxypentanedioic Acid 1,5-Diethyl Ester; (S)-1,5-Diethyl 3-Hydroxypentanedioate; (S)-3-Hydroxy-1,5-pentanedioic Acid Diethyl Ester; (S)-Diethyl 3-Hydroxyglutarate
EINECS	Contact for details

Quality Control

Our (S)-3-Hydroxyglutarate Ethyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is hygroscopic (moisture-sensitive); handle and store under inert atmosphere (e.g., nitrogen) for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.