Description

(3S,3As,5S,6E,10Z,11Ar)-3A,4,5,8,9,11A-Hexahydro-5-Hydroxy-10-(Hydroxymethyl)-3,6-Dimethylcyclodeca[B]Furan-2(3H)-One is a complex, high-purity macrocyclic lactone derivative with significant potential in advanced organic synthesis. This compound matters as a sophisticated chiral building block, enabling the development of novel molecular architectures with precise stereochemistry. It is primarily needed by research and development teams in the pharmaceutical and agrochemical sectors for creating new active ingredients and exploring complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, particularly for complex macrocyclic and polyketide-derived therapeutics.
• Agrochemical Research: Used in the development of new, high-specificity pesticides and herbicides, leveraging its unique stereochemical framework for targeted biological activity.
• Natural Product Synthesis: Acts as a critical intermediate in the total synthesis of complex natural products, aiding in structure-activity relationship (SAR) studies.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes to study enzyme mechanisms and biological pathways.
• Advanced Material Science: Investigated as a monomer or precursor for creating specialized polymers with tailored optical or chiral properties.
• Catalyst Ligand Development: Utilized as a scaffold for developing novel chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	(3S,3As,5S,6E,10Z,11Ar)-3A,4,5,8,9,11A-Hexahydro-5-Hydroxy-10-(Hydroxymethyl)-3,6-Dimethylcyclodeca[B]Furan-2(3H)-One
CAS No.	95298-48-9
Molecular Formula	C15H22O4
Molecular Weight	266.33 g/mol
Synonyms	Cyclodeca[B]furan-2(3H)-one derivative; 5-Hydroxy-10-(hydroxymethyl)-3,6-dimethyl-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (3S,3aR,5S,6E,10Z,11aR)-isomer; Macrocyclic lactone intermediate; Chiral furanone building block
EINECS	Contact for details

Quality Control

Our (3S,3As,5S,6E,10Z,11Ar)-3A,4,5,8,9,11A-Hexahydro-5-Hydroxy-10-(Hydroxymethyl)-3,6-Dimethylcyclodeca[B]Furan-2(3H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity suitable for sensitive R&D applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.