Description

(2S,3R,5R)-3-(Hydroxymethyl)-3-Methyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4,4-Dioxide is a high-purity, advanced pharmaceutical intermediate with a complex bicyclic β-lactam structure. This compound is a critical synthon in the synthesis of novel and potent β-lactam antibiotics, offering a key chiral building block for research and development. It is essential for pharmaceutical manufacturers and research institutions focused on developing next-generation antibacterial agents to combat resistant pathogens.

Application

• Key Intermediate in β-Lactam Antibiotic Synthesis: Serves as a crucial chiral precursor for the production of penems, carbapenems, and other novel β-lactam classes.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new antibacterial compounds.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scalable synthesis of complex antibiotic APIs requiring this specific stereochemistry and functionalization.
• Process Chemistry & Route Scouting: Utilized by chemists to develop and optimize efficient, cost-effective synthetic pathways for advanced antibiotic production.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(2S,3R,5R)-3-(Hydroxymethyl)-3-Methyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4,4-Dioxide
CAS No.	95123-10-7
Molecular Formula	C9H11NO6S
Molecular Weight	261.25 g/mol
Synonyms	(2S,3R,5R)-3-(Hydroxymethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; (2S,3R,5R)-3-(Hydroxymethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid S,S-dioxide; Penem intermediate; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid derivative; Bicyclic β-lactam sulfone; 95123-10-7
EINECS	Contact for details

Quality Control

Our (2S,3R,5R)-3-(Hydroxymethyl)-3-Methyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4,4-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.