Description

D-Threo-Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester is a high-purity, fluorinated carbohydrate derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique difluoro and acetonide-protected structure, enabling precise stereochemical control in the synthesis of complex bioactive molecules. This compound is essential for research and development laboratories and production facilities focused on nucleoside analogs, antiviral agents, and other sophisticated pharmaceutical actives.

Application

• Key Intermediate for Antiviral Drugs: Serves as a vital building block in the synthesis of novel nucleoside reverse transcriptase inhibitors and other antiviral compounds.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic agents targeting viral infections and cancers.
• Synthesis of Fluorinated Nucleosides: The 2,2-difluoro moiety is crucial for creating modified nucleosides with enhanced metabolic stability and binding affinity.
• Process Chemistry & Scale-Up: Employed in the development and commercial-scale manufacturing routes for active pharmaceutical ingredients (APIs).
• Biochemical Probe Development: Useful for creating labeled or modified sugars to study biological pathways and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and specialty chemical companies for bespoke synthesis projects.

Basic Information

Product Name	D-Threo-Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester
CAS No.	95058-93-8
Molecular Formula	C12H18F2O6
Molecular Weight	296.27 g/mol
Synonyms	Ethyl 2-Deoxy-2,2-difluoro-4,5-O-isopropylidene-D-threo-pentonate; 2-Deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-D-threo-pentonic Acid Ethyl Ester; D-Threo-Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester; 95058-93-8; Ethyl 2-deoxy-2,2-difluoro-4,5-O-isopropylidene-D-three-pentonate; Difluoro Acetonide Ethyl Ester Intermediate
EINECS	Contact for details

Quality Control

Our D-Threo-Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance needs for cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This compound should be stored separately from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.