Description

2-Deoxy-2,2-Difluoro-D-Erythro-Pentose is a key fluorinated sugar intermediate with significant synthetic utility. Its primary value lies in its role as a crucial building block for the synthesis of nucleoside analogs, particularly gemcitabine and related active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for manufacturers in the pharmaceutical and fine chemical sectors who require reliable, high-quality raw materials for complex synthesis. We supply this compound to meet the stringent demands of research, development, and commercial-scale production.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of the anticancer drug Gemcitabine and its hydrochloride salt (Gemcitabine HCl).
• Nucleoside Analog Synthesis: Serves as a foundational building block for the development of novel antiviral and anticancer nucleoside analogs.
• Fine Chemical Research: Used in academic and industrial R&D for exploring new fluorinated carbohydrate chemistry and bio-active molecules.
• Process Development: Employed in scaling up and optimizing synthetic routes for gemcitabine-based APIs under cGMP conditions.
• Reference Standard: High-purity material suitable for use as an analytical standard in quality control laboratories.

Basic Information

Product Name	2-Deoxy-2,2-Difluoro-D-Erythro-Pentose
CAS No.	95058-90-5
Molecular Formula	C5H8F2O4
Molecular Weight	170.11 g/mol
Synonyms	2-Deoxy-2,2-difluoro-D-erythro-pentofuranose; 2-Deoxy-2,2-difluoro-D-ribose; 2,2-Difluoro-2-deoxy-D-erythro-pentose; Gemcitabine Intermediate; DFDR; Difluorodeoxyribose; (2R,3R,4S)-2-(Difluoromethyl)tetrahydrofuran-3,4-diol
EINECS	Contact for details

Quality Control

Our 2-Deoxy-2,2-Difluoro-D-Erythro-Pentose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) are provided with every shipment, detailing all critical quality attributes. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards as required for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.