Description

2(1H)-Pyrimidinone, 4-Amino- 1-(2-Deoxy-2,2-Difluoro-α-D- Erythro-Pentofuranosyl)- is a high-purity nucleoside analog, a critical building block in the synthesis of advanced pharmaceutical compounds. Its value lies in its role as a key intermediate for the production of potent antiviral and anticancer therapeutics, where precise molecular structure is paramount for biological activity. This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and scale-up of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor for the manufacture of nucleoside analog antiviral drugs, including chemotherapy agents.
• Anticancer Drug Synthesis: Critical building block in the production of chemotherapeutic compounds that target DNA synthesis in rapidly dividing cells.
• Antiviral Agent Development: Used in research and production of antiviral medications, particularly those targeting viral polymerases.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and molecular biology research to understand nucleotide metabolism.
• Process Development & Scale-up: Utilized by process chemists for route scouting, optimization, and pilot-scale synthesis of complex active pharmaceutical ingredients (APIs).
• Reference Standard: High-purity grades are used as analytical reference standards for quality control and regulatory submissions.

Basic Information

Product Name	2(1H)-Pyrimidinone, 4-Amino- 1-(2-Deoxy-2,2-Difluoro-α-D- Erythro-Pentofuranosyl)-
CAS No.	95058-85-8
Molecular Formula	C9H11F2N3O4
Molecular Weight	263.20 g/mol
Synonyms	4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)pyrimidin-2(1H)-one; 2'-Deoxy-2',2'-difluorocytidine; Gemcitabine Intermediate; dFdC Intermediate; LY-188011 Intermediate; 4-Amino-1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone (enantiomer); Difluorodeoxycytidine; β-2'-Deoxy-2',2'-difluorocytidine
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles to meet the stringent requirements of pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.