Description

(3α,4β)-3-Hydroxy-2,2-Dimethyl-4-(2-Oxopyrrolidine-1-Yl)Chroman-6-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex chroman-based structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly in the areas of central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of proprietary drug candidates and novel APIs.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	(3α,4β)-3-Hydroxy-2,2-Dimethyl-4-(2-Oxopyrrolidine-1-Yl)Chroman-6-Carbonitrile
CAS No.	94535-51-0
Molecular Formula	C16H18N2O3
Molecular Weight	286.33 g/mol
Synonyms	6-Cyano-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)chroman; (3R,4S)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile; Chroman-6-carbonitrile, 3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3R,4S)-; (3R,4S)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)chroman-6-carbonitrile; 94535-51-0; (3α,4β)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
EINECS	Contact for details

Quality Control

Our (3α,4β)-3-Hydroxy-2,2-Dimethyl-4-(2-Oxopyrrolidine-1-Yl)Chroman-6-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.