Description

1-Acetyl-2-(Tetrahydro-2H-Pyran-2-Yl)Isothiourea is a specialized organic compound that serves as a versatile building block in advanced chemical synthesis. Its unique molecular structure, featuring both an acetyl-protected isothiourea moiety and a tetrahydropyranyl (THP) protecting group, makes it a valuable reagent for the controlled introduction of thiourea and guanidine functionalities. This compound is essential for research chemists and process development scientists working in pharmaceutical and agrochemical R&D, where it is used to create novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing guanidine or thiourea pharmacophores.
• Agrochemical Research: Used in the development of new pesticides, herbicides, and fungicides requiring specific nitrogen-sulfur containing heterocycles.
• Peptide Mimetics & Modifications: Facilitates the site-specific incorporation of isothiourea or guanidine groups into peptide chains to alter bioactivity and stability.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with unique properties.
• Catalyst & Ligand Development: Used as a precursor for synthesizing novel organocatalysts or metal-complexing ligands.

Basic Information

Product Name	1-Acetyl-2-(Tetrahydro-2H-Pyran-2-Yl)Isothiourea
CAS No.	94159-71-4
Molecular Formula	C9H16N2O2S
Molecular Weight	216.30 g/mol
Synonyms	1-Acetyl-2-(tetrahydro-2H-pyran-2-yl)-2-thiopseudourea; N-Acetyl-N'-(tetrahydro-2H-pyran-2-yl)isothiourea; 2H-Pyran, 2-[2-[(acetylamino)imino]ethyl]tetrahydro-; THP-Protected Acetyl Isothiourea; 1-Acetyl-2-(THP)isothiourea; Ac-THP-ITU; (Tetrahydro-2H-pyran-2-yl)carbamothioyl acetate
EINECS	Contact for details

Quality Control

Our 1-Acetyl-2-(Tetrahydro-2H-Pyran-2-Yl)Isothiourea is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.