Description

1,3-Bis(Vinylsulfonylacetamido)Propane is a specialized bifunctional crosslinking agent featuring reactive vinyl sulfone groups. This compound is valued for its ability to form stable covalent bonds with nucleophiles such as thiols and amines under mild conditions, enabling precise bioconjugation and material modification. It is primarily utilized by researchers and manufacturers in the life sciences, polymer chemistry, and advanced materials sectors for applications requiring robust and specific molecular linkages.

Application

• Bioconjugation Reagent: For the site-specific crosslinking of proteins, antibodies, peptides, and other biomolecules to create stable conjugates for diagnostics and therapeutics.
• Hydrogel Formation: Acts as a crosslinker in the synthesis of polyethylene glycol (PEG) or other polymer-based hydrogels for drug delivery and tissue engineering.
• Surface Functionalization: Used to modify surfaces (e.g., gold, glass, polymers) with bioactive ligands or to create reactive platforms for further chemical attachment.
• Antibody-Drug Conjugate (ADC) Development: Enables the controlled attachment of cytotoxic payloads to monoclonal antibodies via cysteine or lysine residues.
• Polymer Chemistry: Serves as a crosslinking monomer to introduce sulfone functionality and enhance the mechanical or chemical properties of specialty polymers.
• Affinity Chromatography: Immobilization of ligands onto chromatography resins for the purification of specific proteins or biomolecules.

Basic Information

Product Name	1,3-Bis(Vinylsulfonylacetamido)Propane
CAS No.	93629-90-4
Molecular Formula	C12H18N2O6S2
Molecular Weight	350.41 g/mol
Synonyms	1,3-Propanediylbis[(vinylsulfonyl)acetamide]; N,N'-1,3-Propanediylbis[2-(vinylsulfonyl)acetamide]; BVSAP; Bis(vinylsulfonylacetamido)propane; 2,2'-(Propane-1,3-diylbis(azanediyl))bis(2-oxoethane-1-sulfonyl)ethene; Bifunctional vinyl sulfone crosslinker
EINECS	Contact for details

Quality Control

Our 1,3-Bis(Vinylsulfonylacetamido)Propane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.