Description

(S)-3-(Boc-Amino)-1-Chloro-2-Butanone CAS NO 93371-30-3 is a high-purity chiral building block featuring a protected amino group and a reactive chloro-ketone moiety. This compound is critical for the synthesis of complex, optically active molecules, offering precise stereochemical control in pharmaceutical and agrochemical research. It is primarily utilized by process chemists and R&D scientists in the pharmaceutical industry for the development of active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Peptidomimetic Chemistry: Serves as a crucial building block for constructing non-peptide scaffolds that mimic the structure and function of natural peptides.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure β-amino alcohols and other chiral amines via nucleophilic substitution or reduction of the carbonyl group.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized fine chemicals for client projects.
• Academic & Institutional Research: Used in university and institutional labs for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	(S)-3-(Boc-Amino)-1-Chloro-2-Butanone
CAS No.	93371-30-3
Molecular Formula	C9H16ClNO3
Molecular Weight	221.68 g/mol
Synonyms	1-Chloro-3-[(tert-butoxycarbonyl)amino]-2-butanone, (S)-Form; (S)-1-Chloro-3-(Boc-amino)-2-butanone; (S)-3-[(tert-Butoxycarbonyl)amino]-1-chloro-2-butanone; (S)-N-Boc-3-amino-1-chloro-2-butanone; (S)-1-Chloro-3-(tert-butoxycarbonylamino)-2-butanone; Boc-L-3-Amino-1-chloro-2-butanone; (S)-3-(Boc-Amino)-1-chloro-2-butanone hydrochloride (salt form variant)
EINECS	Contact for details

Quality Control

Our (S)-3-(Boc-Amino)-1-Chloro-2-Butanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and IR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.