Description

Milbemycin A4 Oxime is a semi-synthetic derivative of the naturally occurring milbemycin family, a class of 16-membered macrolides. This compound is valued for its potent anthelmintic and acaricidal properties, offering a high degree of efficacy and a favorable safety profile. It is a critical active pharmaceutical ingredient (API) and agrochemical intermediate, primarily serving the veterinary pharmaceutical and crop protection industries for the development of parasitic control solutions.

Application

• Veterinary Pharmaceutical API: Core ingredient in formulations for parasiticides targeting internal and external parasites in livestock, companion animals, and pets.
• Broad-Spectrum Anthelmintic: Effective against nematodes, including gastrointestinal roundworms and lungworms, in cattle, sheep, goats, and swine.
• Acaricide for Crop Protection: Used in agricultural miticides to control spider mites and other phytophagous mites in high-value crops like fruits, vegetables, and ornamentals.
• Endectocide Formulations: Key component in combination products that provide both internal and external parasite control in a single dose.
• Agrochemical Intermediate: Serves as a crucial building block for the synthesis of advanced, next-generation parasiticidal agents.
• Research & Development: Used in biochemical research to study parasite neuromuscular function and for the development of novel antiparasitic drugs.

Basic Information

Product Name	Milbemycin A4 Oxime
CAS No.	93074-04-5
Molecular Formula	C₃₂H₄₅NO₇
Molecular Weight	555.71 g/mol
Synonyms	Milbemycin A4 Oxime; (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,13R,20R,21R,24S)-6'-Ethyl-21,24-dihydroxy-5',11,13,22-tetramethyl-3,7,19-trioxaspiro[11.16]hexacosa-10,14,16,22-tetraene-2,6,12,20-tetrone 5'-oxime; 5-Oxime of Milbemycin A4; LL-F28249-alpha Oxime; Nemadectin Oxime (related); Z-93074-04-5
EINECS	Contact for details

Quality Control

Our Milbemycin A4 Oxime is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for use as a pharmaceutical intermediate. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.