Description

3-Carboxypropyl Methanethiosulfonate is a specialized organosulfur compound featuring a reactive methanethiosulfonate group linked to a carboxylic acid-terminated alkyl chain. This bifunctional structure makes it a valuable reagent for site-specific protein and peptide modification, enabling the controlled introduction of thiol-reactive groups or cross-links. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and pharmaceutical development for creating stable, well-defined molecular constructs.

Application

• Bioconjugation Reagent: For the site-specific modification of cysteine residues in proteins and antibodies to attach fluorophores, drugs, or other functional molecules.
• Cross-linking Agent: Used in structural biology and material science to create covalent bridges between biomolecules, aiding in the study of protein interactions or the stabilization of complexes.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) and other chemical proteomics strategies to label and identify active-site cysteines.
• Surface Functionalization: Applied to modify gold surfaces or nanoparticles via the thiol-reactive group for biosensor development and diagnostic applications.
• Intermediate in Organic Synthesis: Serves as a building block for synthesizing more complex thiol-reactive compounds and pharmaceutical intermediates.

Basic Information

Product Name	3-Carboxypropyl Methanethiosulfonate
CAS No.	92953-15-6
Molecular Formula	C5H10O4S2
Molecular Weight	198.26 g/mol
Synonyms	3-(Methanethiosulfonyl)propanoic Acid; (3-Carboxypropyl) Methanethiosulfonate; MTS-Propionic Acid; 3-Carboxypropyl MTS; 4-Sulfanylbutanoic Acid S-Methanesulfonothioate; 92953-15-6; CPT-MTS
EINECS	Contact for details

Quality Control

Our 3-Carboxypropyl Methanethiosulfonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and FTIR for identification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is light-sensitive and should be handled under inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.