Description

2-Carboxyethyl Methanethiosulfonate is a specialized organosulfur compound featuring both a methanethiosulfonate (MTS) reactive group and a carboxylic acid functionality. This dual functionality makes it a valuable site-specific protein modification reagent and a versatile chemical building block in advanced synthesis. It is primarily utilized by researchers and manufacturers in the life sciences and fine chemical sectors for bioconjugation, probe development, and the synthesis of novel thiol-reactive compounds.

Application

• Bioconjugation and Protein Labeling: The methanethiosulfonate group selectively reacts with cysteine thiols in proteins and peptides, while the carboxylic acid allows for further coupling or attachment to surfaces, enabling the creation of labeled proteins for diagnostics and research.
• Chemical Probe Synthesis: Serves as a key intermediate for synthesizing activity-based probes (ABPs) and affinity labels used to study enzyme function and identify drug targets.
• Crosslinking Agent: Used to introduce disulfide or thioether linkages between biomolecules or synthetic polymers, facilitating structural studies and material development.
• Pharmaceutical Intermediate: Employed in the research and development of novel therapeutic agents, particularly those targeting sulfur-mediated biological pathways.
• Surface Functionalization: The acid group enables immobilization onto amine-coated surfaces (e.g., chips, beads), creating thiol-reactive platforms for biosensor and microarray applications.
• Polymer Modification: Used to introduce reactive thiol sites or carboxylic acid groups into polymer backbones for creating smart materials and hydrogels.

Basic Information

Product Name	2-Carboxyethyl Methanethiosulfonate
CAS No.	92953-12-3
Molecular Formula	C4H8O4S2
Molecular Weight	184.23 g/mol
Synonyms	3-[(Methylsulfonyl)thio]propanoic Acid; (2-Carboxyethyl) Methyl Disulfide Oxide; MTS-Propionic Acid; Methanethiosulfonic Acid S-(2-Carboxyethyl) Ester; β-Carboxyethyl Methanethiosulfonate; MTSEA-COOH; 2-(Methanethiosulfonato)acetic Acid Homolog
EINECS	Contact for details

Quality Control

Our 2-Carboxyethyl Methanethiosulfonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.