Description

(2S)-8-(3-Hydroxy-3-Methylbutyl)-5,7-Dimethoxy-2α-Phenylchroman is a high-purity chiral flavan derivative, a key synthetic intermediate in advanced pharmaceutical research and development. Its defined stereochemistry and complex molecular architecture make it a valuable building block for creating novel therapeutic agents. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of potential drug candidates targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Medicinal Chemistry Research: Serves as a scaffold or building block for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high purity and stereochemical integrity.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, or NMR for method development, validation, and quality control of related compounds.
• Asymmetric Synthesis: Utilized in chiral pool synthesis or as a starting material for synthesizing more complex natural product analogs and bioactive molecules.

Basic Information

Product Name	(2S)-8-(3-Hydroxy-3-Methylbutyl)-5,7-Dimethoxy-2α-Phenylchroman
CAS No.	92590-02-8
Molecular Formula	C22H28O4
Molecular Weight	356.46 g/mol
Synonyms	(2S)-8-(3-Hydroxy-3-methylbutyl)-5,7-dimethoxy-2-phenyl-2,3-dihydrochromen-4-one; (S)-8-(3-Hydroxy-3-methylbutyl)-5,7-dimethoxy-2-phenylchroman-4-one; 2H-1-Benzopyran-4-one, 8-(3-hydroxy-3-methylbutyl)-5,7-dimethoxy-2-phenyl-, (2S)-; A flavanone derivative; 92590-02-8; (2S)-8-(3-Hydroxy-3-methylbutyl)-5,7-dimethoxy-2-phenyl-4-chromanone
EINECS	Contact for details

Quality Control

Our (2S)-8-(3-Hydroxy-3-Methylbutyl)-5,7-Dimethoxy-2α-Phenylchroman is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and standard pharmacopeial tests. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.