Description

3-Methylbutylzinc Bromide is a highly reactive organozinc reagent, specifically an alkylzinc halide, widely used in modern synthetic organic chemistry. Its primary value lies in its ability to act as a versatile nucleophile for the formation of new carbon-carbon bonds, particularly in cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and efficient methods for constructing complex molecular architectures.

Application

• Key Intermediate in Pharmaceutical Synthesis: Used in Negishi and other transition-metal-catalyzed cross-couplings to introduce the isoamyl (3-methylbutyl) group into complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Employed in the synthesis of novel pesticides, herbicides, and fungicides where the branched alkyl chain can influence biological activity and environmental stability.
• Advanced Material Development: Serves as a precursor for modifying polymer chains or surface coatings, imparting specific hydrophobic or mechanical properties.
• Fine Chemical and Flavor/Fragrance Production: Utilized in the stereoselective synthesis of specialty esters and other compounds that serve as building blocks for high-value aroma chemicals.
• Catalyst and Ligand Research: Acts as a reagent in the development and testing of new catalytic systems for organic transformations.
• Academic and R&D Laboratories: A fundamental tool for methodological development in organic synthesis, enabling research into new coupling methodologies and reaction mechanisms.

Basic Information

Item	Details
Product Name	3-Methylbutylzinc Bromide
CAS No.	92274-43-6
Molecular Formula	C5H11BrZn
Molecular Weight	216.44 g/mol
Synonyms	Isoamylzinc Bromide; (3-Methylbutyl)zinc Bromide; Zinc, bromo(3-methylbutyl)-; Bromo(isoamyl)zinc; Bromo(3-methylbutyl)zinc; 1-Bromo-3-methylbutylzinc; (Isoamyl)zinc bromide
EINECS	Contact for details

Quality Control

Our 3-Methylbutylzinc Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide comprehensive analytical data, including titration for active zinc content and GC analysis for purity and solvent composition. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality management system is designed to meet the stringent requirements of research and development as well as scale-up production environments.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized (store under inert atmosphere). It must be handled and stored under an inert gas (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is between 2°C and 8°C. Keep away from strong acids, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	Typically 0.5 M to 2.0 M in specified solvent (e.g., THF, Diethyl ether)
Assay (Titration)	≥ 95% (as alkylzinc bromide)
Solvent Content (GC)	Balance
Impurities (GC)	Contact for details
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.