Description

3-Benzyloxy-Cyclobutylamine is a versatile chiral amine building block featuring a cyclobutyl core substituted with a benzyloxy group. This compound is of significant value in pharmaceutical research and development, serving as a key intermediate for constructing complex molecules with potential biological activity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the cyclobutylamine scaffold imparts unique biological properties.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Peptidomimetics and Bioisosteres: The structural motif is valuable for designing peptide mimics and bioisosteric replacements in medicinal chemistry programs.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, specialized chemicals.
• Academic and R&D Laboratories: Used in fundamental research exploring new chemical reactions and the properties of strained ring systems.

Basic Information

Product Name	3-Benzyloxy-Cyclobutylamine
CAS No.	92146-77-5
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	3-(Benzyloxy)cyclobutanamine; 3-Benzyloxycyclobutan-1-amine; Cyclobutanamine, 3-(phenylmethoxy)-; 1-Amino-3-benzyloxycyclobutane; 3-(Phenylmethoxy)cyclobutanamine; 3-Benzyloxy-1-aminocyclobutane; BOC-3-Benzyloxy-Cyclobutylamine (protected form); 3-O-Benzyl-1-aminocyclobutanol (tautomeric form)
EINECS	Contact for details

Quality Control

Our 3-Benzyloxy-Cyclobutylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and GC for residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.