Description

[R,(-)]-3-o-Benzyl-D-Glycerol 1,2-Di(Methanesulfonate) CAS NO 91920-59-1 is a high-purity chiral building block and mesylate derivative of D-glycerol. This compound is a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly nucleoside analogs and antiviral agents, due to its ability to introduce specific stereochemistry and functional groups. It is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the production of nucleoside-based antiviral drugs (e.g., reverse transcriptase inhibitors) and other active pharmaceutical ingredients (APIs).
• Antiviral Drug Synthesis: Specifically used in the research and commercial synthesis of compounds targeting viruses such as HIV, hepatitis, and herpes.
• Chiral Building Block: Utilized in asymmetric synthesis to construct complex molecules with defined stereocenters for medicinal chemistry and drug discovery programs.
• Prodrug Development: Serves as a precursor for prodrug strategies, where the mesylate groups can be further modified to enhance drug delivery and bioavailability.
• Bioconjugation & Labeling: Potential use in creating labeled compounds or conjugates for biochemical research and diagnostic applications.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized, high-value chemical entities.

Basic Information

Product Name	[R,(-)]-3-o-Benzyl-D-Glycerol 1,2-Di(Methanesulfonate)
CAS No.	91920-59-1
Molecular Formula	C12H18O7S2
Molecular Weight	338.40 g/mol
Synonyms	(2R)-2-[(Benzyloxy)methyl]-3-[(methylsulfonyl)oxy]propyl methanesulfonate; (R)-3-O-Benzyl-1,2-O-dimethanesulfonylglycerol; D-(-)-3-O-Benzyl-1,2-di-O-methanesulfonylglycerol; (R)-3-O-Benzyl-1,2-di-O-methanesulfonyl-sn-glycerol; 1,2-Di-O-methanesulfonyl-3-O-benzyl-sn-glycerol; (R)-3-Benzyloxy-1,2-propanediol dimethanesulfonate; 91920-59-1; Bn-D-Glycerol dimethanesulfonate
EINECS	Contact for details

Quality Control

Our [R,(-)]-3-o-Benzyl-D-Glycerol 1,2-Di(Methanesulfonate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and specific tests are provided with every shipment. We support compliance with cGMP, ICH Q7, and REACH regulations where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.