Description

1-Naphthalenamine, 4-(4-Chlorophenyl)-1,2,3,4-Tetrahydro-n-Methyl-, (1S,4S)- is a high-purity chiral amine derivative of naphthalene, serving as a critical advanced pharmaceutical intermediate (API). Its value lies in its specific stereochemistry and functional groups, making it an essential building block for the synthesis of complex, biologically active molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or cardiovascular targets.
• Asymmetric Synthesis: Utilized as a building block or chiral auxiliary in stereoselective organic synthesis to create enantiomerically pure compounds.
• Agrochemical Research: Intermediate in the development of novel pesticides or herbicides where specific stereochemistry influences biological activity.
• Material Science: Potential precursor for specialty polymers, liquid crystals, or organic electronic materials requiring naphthalene-based structures.
• Catalyst Ligand Development: Serves as a precursor for synthesizing novel chiral ligands used in homogeneous catalysis.

Basic Information

Product Name	1-Naphthalenamine, 4-(4-Chlorophenyl)-1,2,3,4-Tetrahydro-n-Methyl-, (1S,4S)-
CAS No.	91797-63-6
Molecular Formula	C17H18ClN
Molecular Weight	271.79 g/mol
Synonyms	(1S,4S)-4-(4-Chlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine; (1S,4S)-4-(p-Chlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthylamine; (1S,4S)-N-Methyl-4-(4-chlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; (1S,4S)-4-(4-Chlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine; (1S,4S)-1-Naphthalenamine, 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-N-methyl-; (1S,4S)-rel-4-(4-Chlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency critical for pharmaceutical development. Quality is verified through comprehensive analytical methods including HPLC for chiral purity and assay, along with identity confirmation via IR and NMR. A detailed Certificate of Analysis (COA) documenting purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.