Description

(1S,2R,5S)-(+)-Menthyl (R)-p-Toluenesulfinate is a high-value chiral sulfinate ester, widely recognized as a versatile chiral auxiliary and building block in asymmetric synthesis. Its primary value lies in enabling the stereoselective synthesis of sulfoxides, which are crucial intermediates for pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high enantiomeric purity for their synthetic routes.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce chirality in the synthesis of enantiomerically pure sulfoxides and other sulfur-containing compounds.
• Pharmaceutical Intermediate: A key building block for the development of active pharmaceutical ingredients (APIs) where specific stereochemistry is required for biological activity.
• Agrochemical Synthesis: Employed in the production of chiral herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral catalysts and ligands used in transition metal-catalyzed reactions.
• Academic and Industrial R&D: A critical reagent for methodological development in organic chemistry and process optimization studies.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances that require precise stereochemical control.

Basic Information

Product Name	(1S,2R,5S)-(+)-Menthyl (R)-p-Toluenesulfinate
CAS No.	91796-57-5
Molecular Formula	C₁₈H₂₆O₂S
Molecular Weight	306.46 g/mol
Synonyms	(1S,2R,5S)-(-)-Menthyl (R)-(+)-p-Toluenesulfinate; (R)-(+)-Menthyl p-Toluenesulfinate; (1S,2R,5S)-Menthyl (R)-4-Methylbenzenesulfinate; (+)-Menthyl (R)-(+)-p-Toluenesulfinate; (R)-p-Toluenesulfinic Acid (1S,2R,5S)-Menthyl Ester; (1S,2R,5S)-(-)-Menthyl (R)-4-Toluenesulfinate; Chiral Menthyl Tosylsulfinate; (R)-Menthyl p-Tolylsulfinate
EINECS	Contact for details

Quality Control

Our (1S,2R,5S)-(+)-Menthyl (R)-p-Toluenesulfinate is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation [α]D20	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.