Description

3-Chloro-4-Fluorobenzenesulfonyl Chloride is a high-purity, versatile sulfonyl chloride derivative serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites, enabling the efficient introduction of the 3-chloro-4-fluorophenylsulfonyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for use as a key intermediate in the synthesis of sulfonamide-based drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel sulfonamide drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with the 3-chloro-4-fluorophenylsulfonyl group.
• Material Science Research: Employed in the creation of specialized polymers, liquid crystals, and advanced organic materials.
• Chemical Derivatization: Acts as a sulfonating agent for amines and alcohols in fine chemical and custom synthesis projects.
• Proteomics & Biochemistry: Can be utilized as a reagent for protein labeling and modification studies due to its reactive sulfonyl chloride group.

Basic Information

Product Name	3-Chloro-4-Fluorobenzenesulfonyl Chloride
CAS No.	91170-93-3
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.06 g/mol
Synonyms	1-Chloro-2-fluoro-4-(chlorosulfonyl)benzene; 4-Chloro-3-fluorobenzenesulfonyl chloride; 3-Chloro-4-fluorophenylsulfonyl chloride; 2-Fluoro-4-chlorobenzenesulfonyl chloride; Benzenesulfonyl chloride, 3-chloro-4-fluoro-; 91170-93-3; 3-Cl-4-F-C6H3SO2Cl
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, amines, and oxidizing agents. Due to its reactivity as a strong acid/organic solvent, it should be handled with appropriate personal protective equipment in a controlled environment. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0 - 103.0%
Melting Point	40 - 44 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.