Description

2-Bromo-1-Methanesulfonyl-4-Methylbenzene is a high-purity, versatile sulfone derivative and a key synthetic intermediate in advanced organic chemistry. This compound matters for its role as a crucial building block in the development of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those containing sulfonyl or aryl bromide functional groups for further cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the bromine and sulfone moieties offer valuable sites for structural modification.
• Material Science Research: Acts as a monomer or building block for creating specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The aryl bromide functionality makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, or Sonogashira couplings to form complex biaryl systems.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for metal catalysis or as a core structure in catalyst design for asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and target identification.

Basic Information

Product Name	2-Bromo-1-Methanesulfonyl-4-Methylbenzene
CAS No.	90531-97-8
Molecular Formula	C8H9BrO2S
Molecular Weight	249.13 g/mol
Synonyms	1-Bromo-2-(Methylsulfonyl)-4-Methylbenzene; 2-Bromo-4-Methylphenyl Methyl Sulfone; 4-Methyl-2-Bromophenyl Methyl Sulfone; 2-Bromo-1-(Methylsulfonyl)-4-Methylbenzene; 2-Bromo-4-Methylbenzenesulfonyl Methane; Methyl (2-Bromo-4-Methylphenyl) Sulfone; (2-Bromo-4-methylphenyl)(methyl)sulfone; 90531-97-8
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Methanesulfonyl-4-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.