Description

4-Amino-6-Fluorochroman-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique chroman ring structure functionalized with amino and fluorine substituents. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in the creation of new drug candidates and specialty organic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and cardiovascular diseases.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing chroman-based scaffolds, enabling structure-activity relationship (SAR) studies and lead optimization.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial laboratories for developing new synthetic methodologies and novel chemical entities.
• Agrochemical Synthesis: Potential application as an intermediate in the development of new generation pesticides and herbicides, leveraging the biological activity of the fluorinated chroman structure.

Basic Information

Product Name	4-Amino-6-Fluorochroman-4-Carboxylic Acid
CAS No.	90477-46-6
Molecular Formula	C10H10FNO3
Molecular Weight	211.19 g/mol
Synonyms	4-Amino-6-fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid; 6-Fluoro-4-aminochroman-4-carboxylic acid; 4-Carboxy-4-amino-6-fluorochroman; 4-Amino-6-fluoro-4-chromancarboxylic acid; 90477-46-6; AFCA
EINECS	Contact for details

Quality Control

Our production of 4-Amino-6-Fluorochroman-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured in facilities operating under cGMP principles where applicable. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and specific impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.