Description

2-Propanone, 1,1,1-Trifluoro-3-[(4-Nitrophenyl)Thio]- is a specialized fluorinated ketone building block featuring a nitro-substituted thioether linkage. This compound matters for its unique molecular architecture, which makes it a valuable intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). Industrial and research chemists need this high-purity intermediate for developing novel compounds in agrochemical, pharmaceutical, and material science applications where the trifluoromethyl and nitroarylthio groups impart specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly those targeting specific enzyme inhibitors or receptor modulators.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Acts as a precursor for functionalized polymers or liquid crystals, leveraging its electron-withdrawing groups to tune material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and as a scaffold for constructing complex heterocyclic compounds in R&D laboratories.
• Chemical Research & Development: Essential for method development and exploring new synthetic pathways in academic and industrial research settings.

Basic Information

Product Name	2-Propanone, 1,1,1-Trifluoro-3-[(4-Nitrophenyl)Thio]-
CAS No.	90357-44-1
Molecular Formula	C9H6F3NO3S
Molecular Weight	265.21 g/mol
Synonyms	1,1,1-Trifluoro-3-[(4-nitrophenyl)thio]acetone; 3-[(4-Nitrophenyl)thio]-1,1,1-trifluoroacetone; 4-Nitrophenyl 1,1,1-Trifluoroacetonyl Sulfide; 1,1,1-Trifluoro-3-(4-nitrophenylthio)propan-2-one; 4-Nitrophenyl trifluoroacetonyl sulfide; (4-Nitrophenylthio)trifluoroacetone; TFAPA-4-NPS; 4-NPS-TFA
EINECS	Contact for details

Quality Control

Our 2-Propanone, 1,1,1-Trifluoro-3-[(4-Nitrophenyl)Thio]- is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and industrial use. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.