Description

Boc-Ala-Pro-Nva-4-Chloro-Sbzl is a specialized protected peptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled assembly of complex peptide sequences, offering precise control over stereochemistry and side-chain functionality. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research laboratories engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of novel therapeutic peptide candidates targeting various diseases.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the sequential construction of custom peptide chains on resin.
• Peptidomimetic Design: Serves as a building block for creating modified peptide analogs with enhanced stability, bioavailability, or receptor affinity.
• Biochemical Probe Development: Employed in the production of labeled or tagged peptides for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Contract Research: Essential for fundamental research in peptide chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Boc-Ala-Pro-Nva-4-Chloro-Sbzl
CAS No.	90171-50-9
Molecular Formula	C24H34ClN3O6
Molecular Weight	496.00 g/mol
Synonyms	Boc-Ala-Pro-Nva-4-Cl-Sbzl; tert-Butyloxycarbonyl-alanyl-prolyl-norvalyl-4-chlorobenzyl ester; Boc-L-Ala-L-Pro-L-Nva-4-Chloro-Sbzl; N-(tert-Butoxycarbonyl)-L-alanyl-L-prolyl-L-norvaline 4-chlorobenzyl ester; Boc-Ala-Pro-Nva-OBzl(4-Cl); Peptide Synthesis Intermediate 90171-50-9; Protected Tripeptide Ester
EINECS	Contact for details

Quality Control

Our Boc-Ala-Pro-Nva-4-Chloro-Sbzl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	-40° to -50° (c=1, in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.