Description

3-Amino-2,2-Dimethylcyclobutane-Carboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant building block characterized by its constrained cyclobutane ring system. This compound is a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting neurological and metabolic disorders. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of peptide mimetics and small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry.
• Peptidomimetic Research: Used to introduce rigid, conformationally restricted amino acid analogs into peptide chains to enhance stability and biological activity.
• API Development: Serves as a building block in the research and scale-up production of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthetic routes.
• Academic & Industrial R&D: Fundamental research in organic chemistry and material science exploring novel cyclobutane derivatives.

Basic Information

Product Name	3-Amino-2,2-Dimethylcyclobutane-Carboxylic Acid Hydrochloride
CAS No.	90139-88-1
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	3-Amino-2,2-dimethylcyclobutanecarboxylic acid hydrochloride; 2,2-Dimethyl-3-aminocyclobutanecarboxylic acid HCl; (1R,3S)-3-Amino-2,2-dimethylcyclobutanecarboxylic acid hydrochloride (for enantiomer); Cyclobutane-1-carboxylic acid, 3-amino-2,2-dimethyl-, hydrochloride; 3-AADCB HCl; 3-Amino-DMCB-CA HCl; 90139-88-1
EINECS	Contact for details

Quality Control

Our 3-Amino-2,2-Dimethylcyclobutane-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP starting material applications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.