Description

D-α-Methylleucine Methyl Ester is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the production of complex molecules with precise stereocontrol. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified leucine residues, influencing peptide conformation and stability.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral centers.
• Biochemical Research: Employed as a standard or reagent in metabolic pathway studies and enzyme inhibition assays.
• Fine Chemical Production: An intermediate for manufacturing specialty agrochemicals, flavors, and fragrances requiring specific stereoisomers.

Basic Information

Product Name	D-α-Methylleucine Methyl Ester
CAS No.	90104-03-3
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	Methyl (R)-2-amino-4-methylpentanoate; (R)-2-Amino-4-methylpentanoic acid methyl ester; D-α-Methylleucine methyl ester; (R)-2-Amino-4-methylvaleric acid methyl ester; Methyl D-2-amino-4-methylvalerate; D-tert-Leucine methyl ester (common name variant); (R)-Methyl 2-amino-4-methylpentanoate
EINECS	Contact for details

Quality Control

Our D-α-Methylleucine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.