Description

L-α-Methylleucine Methyl Ester is a high-purity chiral amino acid derivative, specifically engineered as a critical building block for advanced organic synthesis. This compound matters for its role in constructing complex peptide mimetics and pharmaceutical intermediates with precise stereochemical control. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, peptidomimetics, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce sterically hindered, non-proteinogenic amino acid residues.
• Agrochemical Research: Serves as a building block for developing novel herbicides and pesticides with specific chiral activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in catalytic asymmetric reactions to induce stereoselectivity.
• Biochemical Research: Utilized in studies of enzyme-substrate interactions and metabolic pathways involving branched-chain amino acids.
• Fine Chemical Production: Acts as a precursor for specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	L-α-Methylleucine Methyl Ester
CAS No.	90104-02-2
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	L-α-Methylleucine Methyl Ester; (S)-2-Amino-2-methyl-4-methylpentanoic Acid Methyl Ester; Methyl (S)-2-Amino-2-methyl-4-methylpentanoate; Methyl L-2-Amino-2-methyl-4-methylvalerate; L-2-Amino-2-methyl-4-methylpentanoic Acid Methyl Ester; (S)-2-Methyl-2-amino-4-methylpentanoic Acid Methyl Ester; L-tert-Leucine Methyl Ester Derivative
EINECS	Contact for details

Quality Control

Our L-α-Methylleucine Methyl Ester is produced under a strict quality management system to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral GC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment, supporting compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.