Description

Dl-2-Acetamido-6-(Boc-Amino)-4-Hexynoic Acid Dcha is a specialized, protected amino acid derivative featuring both acetyl and tert-butyloxycarbonyl (Boc) protecting groups on a hexynoic acid backbone. This compound is a critical building block in advanced organic synthesis, enabling the controlled construction of complex peptide and peptidomimetic structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including enzyme inhibitors and targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Serves as a protected amino acid component in solid-phase and solution-phase peptide synthesis (SPPS), allowing for the incorporation of non-natural, alkyne-functionalized amino acids.
• Chemical Biology Probes: Used to synthesize labeled peptides or peptidomimetics for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates by modifying the peptide chain.
• Bioconjugation: The alkyne moiety provides a handle for click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), for labeling and conjugating biomolecules.

Basic Information

Product Name	Dl-2-Acetamido-6-(Boc-Amino)-4-Hexynoic Acid Dcha
CAS No.	90102-79-7
Molecular Formula	C19H32N2O5 • C14H23N
Molecular Weight	~ 526.7 g/mol (Free acid) + 213.3 g/mol (DCHA) = ~ 740.0 g/mol (Salt)
Synonyms	N2-Acetyl-N6-(tert-butoxycarbonyl)-Dl-2,6-diamino-4-hexynoic acid dicyclohexylamine salt; (RS)-2-Acetamido-6-[(tert-butoxycarbonyl)amino]hex-4-ynoic acid DCHA salt; Boc-Dap(4-yn, Ac)-OH • DCHA; DL-2-Acetamido-6-(Boc-amino)-4-hexynoic acid DCHA salt; Protected 2,6-Diamino-4-hexynoic Acid Derivative; Alkyne-functionalized Diamino Acid Building Block
EINECS	Contact for details

Quality Control

Our production of Dl-2-Acetamido-6-(Boc-Amino)-4-Hexynoic Acid Dcha adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, chiral purity, and impurity profiles. We support cGMP compliance for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (typically ~50:50)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.