Description

Rebamipide Methyl Ester is a key pharmaceutical intermediate and synthetic precursor. This compound is of significant commercial importance for its role in the production of rebamipide, a gastroprotective agent used in ulcer treatment. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in drug development and synthesis. Our supply ensures high purity and consistency, which are critical for maintaining the integrity of downstream pharmaceutical processes.

Application

• Pharmaceutical Intermediate: The primary application is as a critical synthetic precursor in the commercial manufacturing of Rebamipide API (Active Pharmaceutical Ingredient).
• Research & Development: Used in laboratory-scale synthesis and process optimization studies for new gastroprotective formulations.
• Chemical Synthesis: Serves as a building block for the preparation of related quinolinone derivatives and analogs for biological screening.
• Quality Control & Reference Standard: Employed as a reference compound in analytical method development and validation (e.g., HPLC, LC-MS) for rebamipide production.

Basic Information

Product Name	Rebamipide Methyl Ester
CAS No.	90098-38-7
Molecular Formula	C20H20N2O5
Molecular Weight	368.39 g/mol
Synonyms	2-(4-Chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid methyl ester; Methyl 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1,2-dihydro-4-quinolinyl)propanoate; Rebamipide methyl ester; Rebamipide intermediate; OPC-12759 methyl ester; 4-Quinolinepropanoic acid derivative
EINECS	Contact for details

Quality Control

Our Rebamipide Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.