Description

21-o-Acetyl-21-o-De(3-Carboxy-1-Oxo-2-Propenyl)-2-Demethyl-2-Methoxy-24-Methyl-19-o-Methylhygrolidin 7-Acetate is a complex, semi-synthetic macrolide derivative of interest for advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis and study of novel bioactive molecules, particularly within the antibiotic and antifungal domains. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel macrolide antibiotics with potentially enhanced efficacy or reduced resistance.
• Reference Standard: Used in analytical method development, validation, and quality control for related active pharmaceutical ingredients (APIs).
• Biochemical Research: Tool compound for studying structure-activity relationships (SAR) and the mechanism of action of hygrolidin-class molecules.
• Medicinal Chemistry: Serves as a sophisticated scaffold for the design and optimization of new chemical entities targeting bacterial or fungal infections.
• Process Chemistry Development: Utilized in scaling up and optimizing synthetic routes for complex natural product derivatives.

Basic Information

Product Name	21-o-Acetyl-21-o-De(3-Carboxy-1-Oxo-2-Propenyl)-2-Demethyl-2-Methoxy-24-Methyl-19-o-Methylhygrolidin 7-Acetate
CAS No.	90042-92-5
Molecular Formula	C37H55NO11
Molecular Weight	689.84 g/mol
Synonyms	21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-19-O-methylhygrolidin 7-acetate; Hygrolidin derivative; 19-O-Methylhygrolidin 7,21-diacetate derivative; Macrolide antibiotic intermediate; CAS 90042-92-5
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters including assay, purity, and identified impurities. We support development projects requiring GMP-grade materials and can tailor specifications to meet specific research or regulatory submission needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.