Description

cis-4-tert-Butylcyclohexanecarboxylic Acid CAS NO 943-28-2 is a high-purity, stereochemically defined cyclohexane derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its ability to impart steric bulk and influence molecular conformation. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of sterically hindered active pharmaceutical ingredients (APIs), including potential drug candidates for metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its bulky tert-butyl group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a core component or side-chain modifier in the synthesis of liquid crystals for display technologies, influencing mesomorphic properties.
• Perfumery and Fragrance Chemistry: Acts as a starting material for synthesizing musky or ambery odorants with improved stability and longevity.
• Polymer Additives: Utilized to create specialized monomers for polymers requiring enhanced thermal stability or specific optical characteristics.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in catalytic systems to induce enantioselectivity in chemical transformations.
• Organic Synthesis Research: A valuable reagent for methodological studies in stereoselective synthesis and conformational analysis.

Basic Information

Product Name	cis-4-tert-Butylcyclohexanecarboxylic Acid
CAS No.	943-28-2
Molecular Formula	C11H20O2
Molecular Weight	184.28 g/mol
Synonyms	cis-4-(1,1-Dimethylethyl)cyclohexanecarboxylic Acid; (1r,4r)-4-tert-Butylcyclohexanecarboxylic Acid; trans-4-tert-Butylcyclohexanecarboxylic Acid (isomer); 4-tert-Butylcyclohexanecarboxylic Acid, cis-; 4-(tert-Butyl)cyclohexanecarboxylic Acid; p-tert-Butylcyclohexanecarboxylic Acid; Cyclohexanecarboxylic acid, 4-(1,1-dimethylethyl)-, cis-
EINECS	213-402-4

Quality Control

Our cis-4-tert-Butylcyclohexanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing identity, purity, and isomer content are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isomeric Purity (cis-isomer, GC/HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.