Description

Tetramethyl-1,3-Cyclobutanedione is a high-purity, symmetrical diketone compound valued for its rigid, sterically hindered cyclobutane core. This structure makes it a versatile and critical building block in advanced organic synthesis, particularly for creating complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop novel compounds with specific stereochemical and physical properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug molecules, leveraging its rigid framework to influence the biological activity and metabolic stability of final APIs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where its structural motif can contribute to enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Acts as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Incorporated as a monomer or cross-linking agent to produce high-performance polymers with improved thermal and mechanical properties.
• Flavor & Fragrance Chemistry: Utilized in the synthesis of musk analogs and other specialty aroma chemicals.
• Organic Synthesis Building Block: Employed in Diels-Alder reactions, [2+2] photocycloadditions, and other cycloaddition chemistry to construct complex polycyclic systems.

Basic Information

Item	Detail
Product Name	Tetramethyl-1,3-Cyclobutanedione
CAS No.	933-52-8
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	2,2,4,4-Tetramethyl-1,3-cyclobutanedione; Diketocyclobutane, tetramethyl-; Tetramethylcyclobutanedione; TMCD; 1,3-Cyclobutanedione, 2,2,4,4-tetramethyl-; NSC 66480
EINECS	213-278-5

Quality Control

Every batch of Tetramethyl-1,3-Cyclobutanedione is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee consistent quality and traceability for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	115 - 118 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.