Description

2',6'-Difluoro-5-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Valerophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated aromatic ketone structure fused with a dioxane acetal protecting group. This compound is of critical importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting selective enzyme inhibition. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where it serves as a key building block for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization processes.
• API Synthesis: Serves as a precursor in the production route for complex Active Pharmaceutical Ingredients (APIs) requiring fluorinated aromatic motifs.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Acetal Protecting Group Chemistry: The 5,5-dimethyl-1,3-dioxan-2-yl moiety acts as a protecting group for carbonyl functionalities in complex organic syntheses.

Basic Information

Item	Detail
Product Name	2',6'-Difluoro-5-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Valerophenone
CAS No.	898786-95-3
Molecular Formula	C₁₇H₂₂F₂O₃
Molecular Weight	312.36 g/mol
Synonyms	5-(5,5-Dimethyl-1,3-dioxan-2-yl)-2',6'-difluorovalerophenone; 1-[2,6-Difluoro-5-(5,5-dimethyl-1,3-dioxan-2-yl)pentyl]benzene; 2',6'-Difluoro-5-(5,5-dimethyl-1,3-dioxan-2-yl)valerophenone; Difluorinated Dioxane Valerophenone Intermediate; Benzene, 1-[2,6-difluoro-5-(5,5-dimethyl-1,3-dioxan-2-yl)pentyl]-; Valerophenone, 2',6'-difluoro-5-(5,5-dimethyl-1,3-dioxan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2',6'-Difluoro-5-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Valerophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, and we support development under cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.