Description

4-Chloro-1-(3-Chloro-4-Fluorophenyl)-1-Oxobutane is a high-purity, halogenated organic building block of significant importance in advanced chemical synthesis. This compound serves as a critical intermediate for the development of active pharmaceutical ingredients (APIs) and complex agrochemicals, where its specific substitution pattern enables precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce a functionalized butanoyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine and chlorine substituents for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the research of specialty polymers with unique thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in the preparation of complex organic ligands for catalytic systems used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic and Industrial R&D: Fundamental research chemical for exploring new organic reactions and methodologies in halogenated compound chemistry.

Basic Information

Product Name	4-Chloro-1-(3-Chloro-4-Fluorophenyl)-1-Oxobutane
CAS No.	898761-12-1
Molecular Formula	C10H9Cl2FO
Molecular Weight	235.08 g/mol
Synonyms	4-Chloro-1-(3-chloro-4-fluorophenyl)butan-1-one; 3-Chloro-4-fluorophenyl 4-chlorobutyl ketone; 1-(3-Chloro-4-fluorophenyl)-4-chlorobutan-1-one; γ-Chloro-3'-chloro-4'-fluorobutyrophenone; 4-Chloro-3'-chloro-4'-fluorobutyrophenone; Butan-1-one, 4-chloro-1-(3-chloro-4-fluorophenyl)-; 898761-12-1 (CAS)
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(3-Chloro-4-Fluorophenyl)-1-Oxobutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP standards where applicable, ensuring reliability for critical pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the halogenated nature of the compound, it should be stored separately from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.