Description

3-Benzyloxy-6-(tert-Butyl-Dimethylsilanyloxymethyl)-4-Oxo-4H-Pyran-2-Carboxylic Acid CAS NO 895134-29-9 is a high-purity, advanced pharmaceutical intermediate featuring a protected pyranone carboxylic acid core. This compound is of critical importance for its role as a versatile synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in complex organic synthesis, particularly for projects involving heterocyclic chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates, especially those targeting metabolic and inflammatory pathways.
• Organic Synthesis Reagent: Used in research laboratories for constructing pyranone and heterocyclic scaffolds due to its reactive carboxylic acid and protected hydroxyl groups.
• Prodrug Development: Serves as a precursor for creating prodrug forms, where the benzyloxy and silyl protecting groups allow for controlled release of the active moiety.
• Chemical Biology Research: Employed in the synthesis of molecular probes and tool compounds for studying enzyme mechanisms and biological pathways.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals and high-value materials for advanced applications.

Basic Information

Product Name	3-Benzyloxy-6-(tert-Butyl-Dimethylsilanyloxymethyl)-4-Oxo-4H-Pyran-2-Carboxylic Acid
CAS No.	895134-29-9
Molecular Formula	C₂₁H₃₀O₆Si
Molecular Weight	406.55 g/mol
Synonyms	3-Benzyloxy-6-((tert-butyldimethylsilyloxy)methyl)-4-oxo-4H-pyran-2-carboxylic acid; 3-(Benzyloxy)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxo-4H-pyran-2-carboxylic acid; 4H-Pyran-2-carboxylic acid, 3-(benzyloxy)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxo-; TBDMS-protected pyranone acid; 3-O-Benzyl-6-O-TBDMS-pyranone-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-Benzyloxy-6-(tert-Butyl-Dimethylsilanyloxymethyl)-4-Oxo-4H-Pyran-2-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.