Description

(R)-(+)-1-[(R)-2-(2'-Di-3,5-Xylylphosphinophenyl)Ferrocenyl]Ethyldi-3,5-Xylylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for the efficient and sustainable synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control. The compound, identified by CAS No. 894771-28-9, represents a pinnacle of ligand design for challenging asymmetric hydrogenation and cross-coupling reactions.

Application

• As a privileged ligand for asymmetric hydrogenation of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Catalyst component for enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) to create chiral biaryl structures.
• Key chiral inducer in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Use in academic and industrial R&D for developing novel catalytic methodologies and exploring new reaction spaces.
• Potential applications in the synthesis of agrochemicals and flavors & fragrances where chirality impacts bioactivity or organoleptic properties.
• Component in catalyst libraries for high-throughput screening in process chemistry optimization.

Basic Information

Product Name	(R)-(+)-1-[(R)-2-(2'-Di-3,5-Xylylphosphinophenyl)Ferrocenyl]Ethyldi-3,5-Xylylphosphine
CAS No.	894771-28-9
Molecular Formula	C58H56FeP2
Molecular Weight	870.83 g/mol
Synonyms	(R,R)-BPPFA; (R,R)-BPPFOH; Josiphos ligand derivative; (R)-(+)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; (R,R)-1-[(S)-2-(Di-3,5-xylylphosphino)phenyl]ethylferrocenyl-di-3,5-xylylphosphine; Ferrocenyl phosphine ligand; Chiral Josiphos-type ligand; (R,R)-BPPF-A; (R,R)-BPPF-OH analog
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality protocols to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral integrity, and key spectroscopic data. Our standard quality commitment includes verification of structure by NMR and HPLC, and assessment of enantiomeric purity to meet the exacting standards of process chemistry and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.