Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-(8α,9S)-Cinchonan-9-Yl- Thiourea is a high-value, organocatalytic chiral thiourea derivative. This compound matters as a sophisticated asymmetric catalyst and chiral selector, enabling the synthesis of enantiomerically pure compounds critical for advanced research and development. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions working on stereoselective synthesis, enantioselective reactions, and the development of novel therapeutic agents.

Application

• Asymmetric Organocatalysis: As a chiral hydrogen-bond donor catalyst for enantioselective transformations such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: For the research and scale-up of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Chiral Resolution & Analysis: As a chiral selector or additive in chromatographic methods for the separation and analysis of enantiomers.
• Ligand in Coordination Chemistry: Potential use in the development of chiral metal complexes for catalytic applications.
• Academic & Industrial R&D: A key reagent for methodological development in organic and medicinal chemistry focused on stereocontrol.
• Fine Chemical Production: Enabling the commercial production of specialty chemicals with defined stereochemistry for agrochemicals and materials science.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-(8α,9S)-Cinchonan-9-Yl- Thiourea
CAS No.	890044-38-9
Molecular Formula	C₂₉H₂₅F₆N₃OS
Molecular Weight	577.59 g/mol
Synonyms	(8α,9S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-(9-cinchonan-9-yl)thiourea; Cinchona Alkaloid Thiourea Derivative; (8α,9S)-Cinchonine-based Thiourea Organocatalyst; 9-Cinchonan-9-yl-3,5-bis(trifluoromethyl)phenylthiourea; Chiral Thiourea Catalyst; Takemoto Catalyst Analogue; Asymmetric Hydrogen-Bonding Catalyst; N-(3,5-Bis(trifluoromethyl)phenyl)-N'-((8S,9R)-cinchonan-9-yl)thiourea
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to stringent quality protocols. Every batch is characterized and tested to ensure high chemical purity and chiral integrity. Standard quality checks include identity confirmation, assay by HPLC, and determination of enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your critical R&D and cGMP-aligned processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.