Description

C-[4-(2-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Yl]-Methylamine is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated tetrahydro-pyran scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates.
• CNS Drug Discovery: Used in the synthesis of compounds targeting neurological receptors and pathways.
• Oncology Research: Serves as a precursor for potential kinase inhibitors and other anti-cancer agents.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Utilized in route scouting and scale-up synthesis for clinical trial material.
• Academic Research: Used in universities and institutes for studying fluorinated heterocyclic chemistry and bioactivity.

Basic Information

Product Name	C-[4-(2-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Yl]-Methylamine
CAS No.	889939-78-0
Molecular Formula	C13H18FNO
Molecular Weight	223.29 g/mol
Synonyms	4-(Aminomethyl)-4-(2-fluorophenyl)tetrahydro-2H-pyran; (4-(2-Fluorophenyl)tetrahydro-2H-pyran-4-yl)methanamine; 1-(2-Fluorophenyl)-4-(aminomethyl)tetrahydro-2H-pyran; 4-(2-Fluorophenyl)-4-(aminomethyl)tetrahydro-2H-pyran; 889939-78-0; FC-1133; FC1133
EINECS	Contact for details

Quality Control

Our C-[4-(2-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Yl]-Methylamine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.