Description

n-Succinimidyloxycarbonylheptyl Methanethiosulfonate is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a sulfhydryl-reactive methanethiosulfonate (MTS) group. This compound is engineered for the controlled, site-specific conjugation of biomolecules, enabling the creation of stable thioether bonds. It is a critical tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein labeling, where precise linkage and minimal disruption to biological activity are paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable, or non-cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Protein-Protein/Peptide Conjugation: Facilitates the crosslinking of amine-containing proteins or peptides to thiol-containing partners for structural studies or multimer creation.
• Surface Immobilization & Bioconjugation: Used to functionalize gold surfaces, nanoparticles, or biosensor chips with proteins or ligands via the thiol-reactive group.
• Fluorescent & Affinity Probe Synthesis: Enables the attachment of dyes, biotin, or other reporter molecules to proteins, antibodies, or oligonucleotides for detection and purification.
• Stable Cell-Penetrating Peptide (CPP) Constructs: For creating disulfide-free, stable conjugates of CPPs with cargo molecules to enhance cellular delivery.
• Polymer & Biomaterial Modification: Functionalizes polymers or hydrogel matrices with bioactive peptides or proteins to create advanced biomaterials.

Basic Information

Product Name	n-Succinimidyloxycarbonylheptyl Methanethiosulfonate
CAS No.	887407-50-3
Molecular Formula	C14H22N2O6S2
Molecular Weight	378.47 g/mol
Synonyms	NHS-PEG7-MTS; Succinimidyloxycarbonyl-heptyl methanethiosulfonate; Heptyl MTS NHS ester; 2,5-Dioxopyrrolidin-1-yl 7-((methylsulfonyl)thio)heptanoate; MTS-PEG7-NHS ester; Heterobifunctional crosslinker NHS-PEG7-MTS; Amine-to-Sulfhydryl crosslinker; SM(PEG)7
EINECS	Contact for details

Quality Control

Every batch of n-Succinimidyloxycarbonylheptyl Methanethiosulfonate is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to ensure it meets the exacting standards required for bioconjugation and pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (Functional NHS ester)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.